Synthesis and Analgesic Activity of New Heterocyclic Cyanothioacetamide Derivatives

The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation gave a series heterocyclic derivatives 1,2,3,4-tetrahydropyridine 1,4,5,6,7,8-hexahydroquinoline fragment. resulting were tested for analgesic activity in vivo. Some the prepared showed an antinociceptive effect superior to that ketorolac dynamics.